Welcome to the
Synthetic Microbiology Lab.
Our Mission.
Rational Engineering of Synthetic Microbes for Sustainable Bioproduction
We develop experimental tools and computational models that allow us to better understand the intricate genetic makeup of bacteria. Further, we want to apply the generated tools and knowledge to engineer new synthetic bacteria capable to efficiently and safely produce value-added chemicals on the basis of renewable resources.
For more info on our research click here
News.
September 1st, 2024
The Synmibi-Family is delighted to welcome its new member Nicolas Jaenisch! Following a succesful MSc-Thesis in our group, Nic will continue to engage in new endeavours on the data-driven engineering of bacterial genetic parts. We are happy to welcome him in our lab!
May 22nd, 2024
!New Paper! In this article, we develop a resource-efficient combination of high-throughput screening and active machine learning to evolve new-to-nature gold-containing enzymes. The data-driven approach drastically enhances the search for improved variants within very large sequence spaces leading to boosted hit rates for the ML-guided directed evolution process.
The results of this interdisciplinary collaborative effort can be found in an open access publication here. The image to the left is the AI-generated cover image we were honoured to provide for the corresponding issue.
Feb 1st, 2024
The Synmibi-Family is growing! Welcome to the group, Thomas Kinateder (left) and Clemens Hausmann (right). Thomas and Clemens will complement our efforts in the biosensing and strain engineering kindly supported by generous ERC funding. Delighted to have you on board!
December 13th, 2023
!New Paper! In this article, we review state-of-the-art methods for high-throughput sequence-function mapping in synthetic biology. Such methods have an enormous potential to boost our capabilities in the engineering of synthetic (micro-)biological system, as they deliver big data for advanced modelling approaches and in silico design tools. The open access publication available here!
November 6th, 2023
!New Paper! In this study, we built an artificial, ruthenium enzyme that catalyzes carbon-carbon coupling in an atroposelective manner. Congratulations to Tobias and our collaborators from the Ward and Sparr groups (Uni Basel). Here you can find the open access publication!
September 5th, 2023
Great news! The SynMiBi Lab will receive generous funding via an ERC Starting Grant from the European Commission! The project BiosenSAI will commence in 2024 and chart new grounds in the engineering and design of novel biosensors for various biotech applications. !Many thanks to the team! More info can be found here.
February 2nd, 2023
!New Paper! Check out our work shedding new light on sequence determinants of translation in bacteria! Several cool and surprising findings enabled by ultradeep sequence-function mapping with DNA recorders. The truth's in the data! Check out the open access publication!
February 1st, 2023
And the team is growing! Today, Charlotte Desczyk had her first day in the SynMiBi Lab. She is the second PhD student in Regensburg working on an exciting research project [learn more]. Great to have you, Charlotte!
HAPPY NEW YEAR 2023
October 26th, 2022
Great news! Our new technician, Yvonne Hader, has joined the lab today. She is very experienced and will help us in various aspects of research, teaching and organization. Welcome to the group, Yvonne!
October 18th, 2022
Today, the first PhD student in Regensburg has started: Ricardo Farrera Muro. We are very happy that he joins the SynMiBi Family and wish him an excellent start. Welcome Ricardo! [learn more about Ricardo's research]
June 1st, 2022
The SynMiBi Lab is born at the University of Regensburg. Very exciting endeavours ahead in research and teaching!
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