Our Research...

...aims at the construction of synthetic microbes with new-to-nature properties to enable sustainable, bio-based production of value-added goods.

We combine molecular biology, chemistry and data science in an interdisciplinary approach to better understand key genetic players and cellular processes in bacteria in order to ultimately rationalize and thus streamline their engineering.


We study gene regulation in bacteria to enable rational expression level engineering and design.

HTP Sequence-Function Mapping

We develop molecular tools and experimental methods to link genetic sequence with biological function in high throughput (HTP). 

Metabolic Engineering

We engineer microbes with targets ranging from single proteins or enzymes to entire metabolic networks

Data-driven Modelling

We exploit our experimental data to model sequence-function relationsships in order to predict and design key properties of microbes.

"What I cannot create, I do not understand.

Richard P. Feynman, 1988

© 2022 Markus Jeschek. All rights reserved.