SynMiBi.

Research Synopsis

In my PhD, I work on the directed evolution of artificial metalloenzymes by machine learning-guided engineering and in vivo selection. By integrating these highly versatile artificial enzymes into the metabolism of Escherichia coli, the throughput of directed evolution campaigns can be drastically increased. At the same time, metabolic pathways not found in nature can be established. Eventually, this could lead to novel and sustainable production processes relying on microbes equipped with a new-to-nature biocatalytic reaction repertoire.