Simon Höllerer, MSc
PhD Student @ETHZ

Contact

D-BSSE, ETHZ

simon[dot]hoellerer[at]bsse[dot]ethz[dot]ch

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Research Synopsis

In my PhD, I develop a novel high-​throughput platform (uASPIre) for sequence-​function mapping of gene regulatory elements in Escherichia coli. I combine a recombinase-based DNA recorder with next-​generation sequencing, which enables us to record sequence-​function data of millions of genetic variants with high phenotypic and temporal resolution at low experimental effort. I capitalize on these features to develop an in-depth understanding of key sequence determinants governing translation in bacteria.

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